Simulating an AUTOEXEC.BAT for OS/2 sessions

To simulate an AUTOEXEC.BAT for OS/2 sessions you can change the 
\CONFIG.SYS  statement for OS2_SHELL to something like 

 
  SET OS2_SHELL=C:\OS2\CMD.EXE /K C:\AUTOEXEC.CMD

In this example the program AUTOEXEC.CMD is executed for every new OS/2 
session. (see also Special filenames) 

You may use this feature to set LIBPATHSTRICT in every OS/2 session ( 
CONFIG.SYS statements used by OS/2) 

Source:  The OS/2 WARP Survival Guide